Organ Size Control Is Dominant over Rb Family Inactivation to Restrict Proliferation In Vivo
نویسندگان
چکیده
منابع مشابه
Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo.
In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, deletion of the entire Rb gene family in mature hepatocytes is not sufficient fo...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2014
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2014.06.025